This symposium considers combining two methodologies— collaborative codesign and data-driven analysis—to realize the full potential of supercomputing. Our scope includes applications, system software, workflows, health of hardware. Today’s HPC centers store vast sums of information, yet using this data presents demanding challenges. Much of the data-driven challenge has to do with discovering, accessing, and analyzing the right data. Codesign also presents formidable challenges. For example, how can a codesign development use the data collected on current systems to facilitate the design of next-generation supercomputers and successfully support our upcoming environments. Quantitative codesign offers a collaborative evidence-based approach to address our existing needs and our upcoming ambitions. This symposium will bring together leaders in the field to review current efforts across centers and discuss areas that show potential.